Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview
نویسندگان
چکیده
منابع مشابه
Thermogelling properties of purified poloxamer 407
Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Easy preparation of poloxamer 407 based sterile injectable for...
متن کاملMechanical, rheological and release behaviors of a poloxamer 407/ poloxamer 188/carbopol 940 thermosensitive composite hydrogel.
The aims of this study were to prepare a thermosensitive composite hydrogel (TCH) by mixing 24% (w/v) poloxamer 407 (P407), 16% (w/v) poloxamer 188 (P188) and 0.1% (w/v) carbopol 940 (C940), and to determine the effect of natural borneol/ (2-hydroxypropyl)-β-cyclodextrin (NB/HP-β-CD) inclusion complex on the phase transition temperature, mechanical, rheological properties, and release behaviors...
متن کاملMicellar systems of poloxamer 407 and 403 for quercetin delivery
The use of poloxamers (PL) have been one of the most widely strategies used for drug delivery systems. The copolymer Poloxamer 407 is a non-ionic surfactant consisting of polioxyethylene (POE) and polioxypropylene (POP) that has many pharmaceutical applications due to its thermoreversible properties. PL are biocompatible and for this reason, are very attractive as carrier systems for administra...
متن کاملRheological Properties of Poloxamer 407 Solutions and Gels
The main objective of this work is to characterize the rheological behavior of poloxamer 407 solutions and gels in various shear flow fields.
متن کاملThe Effect of Poloxamer 407-Based Hydrogel on the Osteoinductivity of Demineralized Bone Matrix
BACKGROUND Demineralized bone matrix (DBM) is used for bone healing due to its osteoinductivity, but it requires a carrier for clinical application. Here, we report the effects on the osteoinductivity of DBM by use of a poloxamer 407-based hydrogel as the carrier, compared to sterile water. METHODS DBM-W and DBM-H represent 27 wt% of DBM with sterile water and DBM with a poloxamer 407-based h...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2018
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics10030159